Description

5-Methyl-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carbonitrile is a high-value, multi-functional boronic ester derivative used as a key synthetic intermediate. This compound matters for its role in enabling complex molecular construction, particularly in the synthesis of active pharmaceutical ingredients (APIs) and advanced materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in cross-coupling reactions and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronate ester coupling partner for the formation of carbon-carbon bonds, essential for constructing complex heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging the pyridine-boronate core structure.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient pyridine core.
• Chemical Biology & Proteomics: Acts as a valuable probe or linker in the development of chemical tools for studying biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	5-Methyl-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carbonitrile
CAS No.	2304634-94-2
Molecular Formula	C13H17BN2O2
Molecular Weight	244.10 g/mol
Synonyms	2-Cyano-5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methylpicolinonitrile; 5-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile; 5-Methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile; Pinacol 5-Methyl-2-cyanopyridine-3-boronate
EINECS	Contact for details

Quality Control

Our 5-Methyl-3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity. Recommended storage temperature is 2-8°C for extended periods, though short-term storage at 15-25°C is acceptable.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.