Description

1-Azetidinecarboxylic Acid, 3-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]-, 1,1-Dimethylethyl Ester is a high-value, multi-functional chemical building block that combines an azetidine core with a pyrazole-boronic ester moiety. This compound matters for its role as a key intermediate in modern pharmaceutical discovery, particularly in the synthesis of complex molecules via cross-coupling reactions. It is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially for small molecule therapeutics targeting various disease pathways.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester functional group makes it an ideal substrate for palladium-catalyzed cross-coupling to form carbon-carbon bonds, a cornerstone of modern medicinal chemistry.
• Protease Inhibitor Research: The azetidine scaffold is a privileged structure in the design of protease inhibitors, making this compound valuable for research in virology and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require complex heterocyclic architectures.
• Chemical Biology & Probe Development: Serves as a versatile handle for creating chemical probes to study biological processes and protein function.
• Material Science Research: Potential use as a monomer or precursor in the development of advanced polymers with specific thermal or mechanical properties.

Basic Information

Product Name	1-Azetidinecarboxylic Acid, 3-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]-, 1,1-Dimethylethyl Ester
CAS No.	2304634-91-9
Molecular Formula	C17H28BN3O4
Molecular Weight	349.24 g/mol
Synonyms	tert-Butyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate; 1-Boc-3-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]azetidine; 3-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylic acid tert-butyl ester; Azetidine-1-carboxylic acid, 3-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester; 1-N-Boc-3-(5-(pinacolboryl)pyrazol-1-yl)azetidine
EINECS	Contact for details

Quality Control

Our production of 1-Azetidinecarboxylic Acid, 3-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization using techniques including NMR, HPLC, and LC-MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.