Description

2H-Pyran, Tetrahydro-4-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]- is a high-value, advanced pharmaceutical intermediate featuring a versatile boronic ester functional group. This compound is critical for enabling key carbon-carbon bond-forming reactions, such as Suzuki-Miyaura cross-couplings, which are foundational to modern medicinal chemistry and materials science. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for oncology and central nervous system (CNS) targets.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable organoboron reagent for palladium-catalyzed cross-coupling to construct biaryl and other conjugated systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex boronate intermediates.
• Materials Science Research: Employed in the development of organic electronic materials, including polymers and small molecules for OLEDs and OFETs.
• Chemical Biology & Probe Development: Utilized as a versatile handle for bioconjugation and the synthesis of molecular probes for diagnostic applications.
• Process Chemistry & Scale-Up: Provides a reliable and scalable intermediate for optimizing synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	2H-Pyran, Tetrahydro-4-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-
CAS No.	2304634-36-2
Molecular Formula	C₁₄H₂₃BO₄
Molecular Weight	266.14 g/mol
Synonyms	4-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)tetrahydro-2H-pyran; Tetrahydro-4-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]-2H-pyran; 4-Methylenetetrahydro-2H-pyran-4-ylboronic acid pinacol ester; (4-Methylenetetrahydropyran-4-yl)boronic acid pinacol ester; 2304634-36-2; THP-protected vinyl boronic ester pinacol.
EINECS	Contact for details

Quality Control

Our production of 2H-Pyran, Tetrahydro-4-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.