Description

[1,1'-Biphenyl]-3,5-Dicarboxylic Acid, 4'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 3,5-Diethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a biphenyl core functionalized with a boronic ester pinacol group. This compound is a critical Suzuki-Miyaura cross-coupling reagent, enabling the efficient construction of complex biaryl structures essential in modern drug discovery. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for creating carbon-carbon bonds between aromatic rings.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with complex aromatic backbones.
• Material Science & OLED Development: A precursor for constructing organic semiconductors, ligands for catalysts, and emissive layers in organic light-emitting diodes (OLEDs).
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: Essential reagent for methodological development and synthetic chemistry research in academic and CRO laboratories.

Basic Information

Product Name	[1,1'-Biphenyl]-3,5-Dicarboxylic Acid, 4'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 3,5-Diethyl Ester
CAS No.	2304634-29-3
Molecular Formula	C26H33BO6
Molecular Weight	452.35 g/mol
Synonyms	4'-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-3,5-dicarboxylic acid 3,5-diethyl ester; 3,5-Diethyl 4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-3,5-dicarboxylate; Biphenyl-3,5-dicarboxylic acid, 4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, diethyl ester; Biphenyl boronic ester pinacol; Aryl boronic ester intermediate CAS 2304634-29-3
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ rigorous analytical techniques including HPLC, NMR (1H, 13C, 11B), and GC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged exposure to ensure optimal stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.