Description

Pyridine, 1-Cyclopropyl-1,2,3,6-Tetrahydro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional heterocyclic building block that combines a pyridine core with a cyclopropyl group and a pinacol boronate ester. This compound is engineered to serve as a critical intermediate in advanced organic synthesis, enabling efficient carbon-carbon and carbon-heteroatom bond formation. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester functional group makes it an excellent partner for palladium-catalyzed cross-coupling, a fundamental reaction in medicinal chemistry and material science.
• Agrochemical Research: Used in developing new generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a scaffold for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science & Organic Electronics: Building block for synthesizing conjugated polymers and small molecules for applications in organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	Pyridine, 1-Cyclopropyl-1,2,3,6-Tetrahydro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	2304631-68-1
Molecular Formula	C17H26BNO2
Molecular Weight	287.21 g/mol
Synonyms	1-Cyclopropyl-1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-cyclopropyl-1,2,3,6-tetrahydropyridine; 1-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 1-Cyclopropyl-1,2,3,6-tetrahydropyridin-4-ylboronic acid pinacol ester; B-[1-Cyclopropyl-1,2,3,6-tetrahydro-4-pyridinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 2304631-68-1
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and LC-MS. Our quality commitment ensures the material meets the stringent requirements for research and pre-clinical development. Specifications and COAs are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability, as the boronate ester moiety may be sensitive to prolonged exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.