Description

1H-Indazole, 1,5-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative of a dimethyl-substituted indazole. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile Suzuki-Miyaura cross-coupling reagent for constructing complex molecular architectures. It is essential for R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a stable boronate ester coupling partner for the formation of carbon-carbon bonds, essential in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand Synthesis for Catalysis: Employed in the creation of novel N-heterocyclic ligands for transition metal catalysis.
• Organic Electronic Materials: Serves as a building block for π-conjugated systems in OLEDs, OFETs, and other optoelectronic devices.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	1H-Indazole, 1,5-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	2304008-17-9
Molecular Formula	C₁₅H₂₁BN₂O₂
Molecular Weight	272.15 g/mol
Synonyms	1,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,5-dimethyl-1H-indazole; 1,5-Dimethyl-1H-indazole-4-boronic acid pinacol ester; 1,5-Dimethylindazole-4-boronic acid pinacol ester; (1,5-Dimethyl-1H-indazol-4-yl)boronic acid pinacol ester; 2304008-17-9; 1,5-Dimethyl-4-(pinacolatoboryl)-1H-indazole
EINECS	Contact for details

Quality Control

Every batch of 1H-Indazole, 1,5-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured and tested under a strict Quality Management System (QMS). We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with each shipment, and we support audits for cGMP, ISO, and other regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.