Description

4-Amino-2-(Trifluoromethyl)Benzaldehyde Hydrochloride is a high-value, multifunctional aromatic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of an aldehyde group, a primary amine (as a hydrochloride salt), and a trifluoromethyl substituent, enabling precise molecular construction. This compound is critically needed by R&D chemists and process developers in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a critical building block for developing next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms for improved pest selectivity and environmental persistence.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts, facilitating asymmetric synthesis and challenging bond-forming reactions.
• Functional Material Precursor: Employed in the research and development of advanced materials, including liquid crystals, organic semiconductors, and polymers with tailored electronic or optical properties.
• Chemical Biology Probe Synthesis: Utilized to create labeled compounds and molecular probes for studying biological pathways and target engagement in drug discovery.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global fine chemical market.

Basic Information

Product Name	4-Amino-2-(Trifluoromethyl)Benzaldehyde Hydrochloride
CAS No.	2288710-41-6
Molecular Formula	C8H7ClF3NO
Molecular Weight	225.60 g/mol
Synonyms	2-(Trifluoromethyl)-4-aminobenzaldehyde hydrochloride; 4-Amino-2-trifluoromethylbenzaldehyde HCl; 4-Amino-α,α,α-trifluoro-o-tolualdehyde hydrochloride; 2-Trifluoromethyl-4-aminobenzaldehyde hydrochloride; 4-Amino-2-(trifluoromethyl)benzenecarboxaldehyde hydrochloride; 4-Formyl-3-(trifluoromethyl)aniline hydrochloride; (4-Amino-2-(trifluoromethyl)phenyl)methanol hydrochloride (tautomer)
EINECS	Contact for details

Quality Control

Our 4-Amino-2-(Trifluoromethyl)Benzaldehyde Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and development. Certificates of Analysis (COA) with full traceability are provided to guarantee consistency, reliability, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.