Description

7-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indole-2,3-Dione is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critically important as a key building block in modern synthetic chemistry, enabling efficient cross-coupling reactions for the construction of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A pivotal boron-containing precursor for constructing biaryl and heterobiaryl structures in medicinal chemistry.
• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides that require specific heterocyclic architectures.
• Material Science Research: Employed in the synthesis of organic electronic materials and ligands for catalytic systems.
• Chemical Biology Probes: Facilitates the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Process Chemistry Development: Provides a stable, handleable boronate source for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	7-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indole-2,3-Dione
CAS No.	2281899-15-6
Molecular Formula	C14H16BNO4
Molecular Weight	273.10 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isatin; 7-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2,3-dione; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole-2,3-dione; 7-Isatinboronic acid pinacol ester; 7-Boronated isatin pinacol ester; 7-Boronoisatin pinacol ester; 7-(Pinacolatoboryl)isatin; CAS 2281899-15-6
EINECS	Contact for details

Quality Control

Our 7-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indole-2,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under quality standards appropriate for your application phase, from research to GMP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.