Description

(2S)-Boc-Pro(2-Ethyl)-Oh is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a 2-ethyl substituted proline core. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise control over molecular conformation and biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, particularly for developing protease inhibitors, receptor modulators, and other therapeutic agents.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce constrained proline analogs, enhancing peptide stability and bioavailability.
• Drug Discovery: Employed in medicinal chemistry for structure-activity relationship (SAR) studies to optimize lead compounds targeting various diseases.
• Bioconjugation: Acts as a specialized linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Utilized to create labeled or modified peptides for studying enzyme mechanisms and protein-protein interactions.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemistry research in academic and corporate laboratories.

Basic Information

Product Name	(2S)-Boc-Pro(2-Ethyl)-Oh
CAS No.	2272518-88-2
Molecular Formula	C₁₂H₂₁NO₄
Molecular Weight	243.30 g/mol
Synonyms	(2S)-1-(tert-Butoxycarbonyl)-2-ethylpyrrolidine-2-carboxylic Acid; Boc-2-Ethyl-L-proline; (S)-1-Boc-2-ethylproline; tert-Butyl (2S)-2-ethyl-2-carboxypyrrolidine-1-carboxylate; (2S)-2-Ethyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic Acid; (S)-2-Ethyl-1-Boc-proline; Boc-Pro(2-Et)-OH
EINECS	Contact for details

Quality Control

Our (2S)-Boc-Pro(2-Ethyl)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from HPLC, NMR, and MS, confirming compliance with customer specifications and industry standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.