Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Thiazole is a high-value organoboron building block, specifically a thiazole-substituted pinacol boronic ester, essential for modern cross-coupling reactions. Its core value lies in enabling the precise and efficient synthesis of complex molecules, particularly in pharmaceutical and agrochemical research where the trifluoromethyl-thiazole motif is pharmacologically significant. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-couplings for synthesizing novel drug candidates, especially those targeting kinases and other enzymes.
• Agrochemical Synthesis: Used to incorporate the bioactive trifluoromethyl-thiazole moiety into new herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLEDs and semiconductors, with tailored electronic properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for studying biological pathways and diagnostics.
• Custom Synthesis & Contract Manufacturing: A critical reagent for CROs and CDMOs offering bespoke chemical synthesis services to clients.
• Academic Research: Used in university and institutional labs for methodological development in organometallic chemistry and catalysis studies.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Thiazole
CAS No.	2256758-32-2
Molecular Formula	C10H13BF3NO2S
Molecular Weight	279.09 g/mol
Synonyms	2-(Trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)-1,3-thiazole; 2-(Trifluoromethyl)thiazole-4-boronic acid pinacol ester; 4-(Pinacolatoboryl)-2-(trifluoromethyl)thiazole; 2-Trifluoromethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-thiazole
EINECS	Contact for details

Quality Control

Every batch of 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Thiazole undergoes rigorous analytical testing to ensure high purity and consistency suitable for sensitive cross-coupling applications. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain optimal purity and reactivity. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.