Description

4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol is a high-value, functionalized pyridine derivative containing a pinacol boronate ester group, making it a crucial intermediate in modern synthetic chemistry. This compound matters because it serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly in creating complex heterocyclic cores found in kinase inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific biphenyl or aryl-heteroaryl linkages.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of chemical probes used in target identification and validation studies.
• Catalyst & Ligand Development: Serves as a precursor for creating novel bidentate or polydentate ligands used in homogeneous catalysis.
• Academic & Contract Research: Essential for methodological development in organic synthesis and for constructing compound libraries for high-throughput screening.

Basic Information

Item	Detail
Product Name	4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ol
CAS No.	2256755-28-7
Molecular Formula	C₁₂H₁₈BNO₃
Molecular Weight	235.09 g/mol
Synonyms	2-Hydroxy-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-ol; 4-Methyl-5-(pinacolatoboryl)pyridin-2-ol; 4-Methyl-5-(pinacolboron)pyridin-2-ol; 2-Pyridinol, 4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic acid, B-(2-hydroxy-4-methyl-5-pyridinyl)-, pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to current Good Manufacturing Practice (GMP) principles where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.