Description

2H-Pyran, Tetrahydro-4-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl]- is a high-value, advanced pharmaceutical intermediate featuring a versatile boronic ester functional group. This compound is critical for enabling key carbon-carbon bond-forming reactions, such as the Suzuki-Miyaura cross-coupling, which is fundamental to modern medicinal chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex organic molecules. Its well-defined structure offers precise reactivity, making it an essential building block for innovators.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring complex boronic acid derivatives.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a tool compound for bioconjugation and the development of chemical probes targeting biological systems.
• Organic Synthesis Building Block: Provides a protected boronic acid handle for multi-step synthetic routes in academic and industrial R&D laboratories.
• Ligand and Catalyst Development: Used in the preparation of novel ligands for transition metal catalysis and organocatalysts.

Basic Information

Product Name	2H-Pyran, Tetrahydro-4-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl]-
CAS No.	2249826-22-8
Molecular Formula	C12H23BO4
Molecular Weight	242.12 g/mol
Synonyms	4-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)tetrahydro-2H-pyran; Tetrahydro-2H-pyran-4-ylmethylboronic acid pinacol ester; (Tetrahydro-2H-pyran-4-ylmethyl)boronic acid pinacol ester; THP-methyl-Bpin; 4-(Pinacolatoborylmethyl)tetrahydropyran
EINECS	Contact for details

Quality Control

Our production of 2H-Pyran, Tetrahydro-4-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl]- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.