Description

1,3,2-Dioxaborolane, 2-[5-Fluoro-2-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl- is a high-value, organoboron building block featuring a pinacol boronic ester group attached to a fluorinated aromatic ring. This compound is critical for enabling advanced cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern pharmaceutical and agrochemical synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly those containing biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides that require fluorinated aromatic components.
• Material Science Research: Serves as a precursor for creating organic electronic materials, including polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes and tool compounds for target validation and drug discovery campaigns.
• Process Chemistry & Scale-up: Provides a stable and handleable boronate source for optimizing large-scale manufacturing routes for fine chemicals.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[5-Fluoro-2-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	2247942-49-8
Molecular Formula	C13H15BF4O2
Molecular Weight	290.07 g/mol
Synonyms	5-Fluoro-2-(trifluoromethyl)phenylboronic acid pinacol ester; [5-Fluoro-2-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(5-Fluoro-2-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Fluoro-2-trifluoromethylbenzeneboronic acid pinacol ester; (5-Fluoro-2-(trifluoromethyl)phenyl)boronic acid pinacol ester; Pinacol [5-fluoro-2-(trifluoromethyl)phenyl]boronate
EINECS	Contact for details

Quality Control

Our production of 1,3,2-Dioxaborolane, 2-[5-Fluoro-2-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl- adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified via advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.