Description

1-Phenyl-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)imidazo[1,5-a]pyridine is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those containing imidazopyridine and biphenyl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient formation of carbon-carbon bonds between aryl and heteroaryl groups under mild conditions.
• Organic Light-Emitting Diode (OLED) Material Research: Serves as a precursor for developing electron-transport or host materials in optoelectronic devices.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides with complex aromatic structures.
• Ligand and Catalyst Development: Acts as a precursor for creating novel bidentate ligands for transition metal catalysis.
• Academic & Industrial R&D: A versatile tool for synthetic organic chemists exploring new chemical spaces and reaction methodologies.

Basic Information

Product Name	1-Phenyl-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)imidazo[1,5-a]pyridine
CAS No.	2247546-38-7
Molecular Formula	C25H25BN2O2
Molecular Weight	396.29 g/mol
Synonyms	1-Phenyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]imidazo[1,5-a]pyridine; 2-(4-(1-Phenylimidazo[1,5-a]pyridin-3-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Phenyl-3-(4-(pinacolatoboryl)phenyl)imidazo[1,5-a]pyridine; Imidazo[1,5-a]pyridine, 1-phenyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; CAS 2247546-38-7; Boronic acid, [4-(1-phenylimidazo[1,5-a]pyridin-3-yl)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our production of 1-Phenyl-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)imidazo[1,5-a]pyridine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling reactions. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP-compliant manufacturing for advanced pharmaceutical applications, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially air/moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.