Description

(E)-2-(5-Fluoro-2-Methylstyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate belonging to the class of styryl boronic esters. This compound is a critical building block in modern synthetic organic chemistry, enabling the precise construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing a biaryl or styryl motif for oncology, CNS, and antiviral therapies.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between its boronic ester group and organic halides, a cornerstone reaction for creating complex, functionalized molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Serves as a monomer or building block for developing organic electronic materials, such as OLEDs (Organic Light-Emitting Diodes) and conductive polymers.
• Chemical Biology & Probe Development: Employed in the creation of fluorescent probes, bioconjugation reagents, and other tools for diagnostic and life science research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-fidelity boronic ester chemistry.

Basic Information

Product Name	(E)-2-(5-Fluoro-2-Methylstyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2246919-02-6
Molecular Formula	C₁₇H₂₄BFO₂
Molecular Weight	290.18 g/mol
Synonyms	5-Fluoro-2-methylstyrylboronic acid pinacol ester; (E)-2-(5-Fluoro-2-methylstyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (E)-1-(5-Fluoro-2-methylphenyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethene; 5-Fluoro-2-methylstyrylBpin; (E)-2-(5-Fluoro-2-Methylstyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane; Boronic acid, B-[(1E)-2-(5-fluoro-2-methylphenyl)ethenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our (E)-2-(5-Fluoro-2-Methylstyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization using HPLC, GC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and mass spectrometry to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with client specifications and internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Isomeric Purity (E/Z Ratio)	≥ 98:2 (E/Z)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.