Description

2-((1,4-Dioxaspiro[4.5]decan-8-ylidene)methyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity, advanced boronic ester building block designed for sophisticated organic synthesis. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is an essential reagent for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality intermediates for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for complex spirocyclic and fused-ring systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific, sterically hindered boronic ester motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and bioconjugates for studying biological processes and target engagement.
• Academic & R&D Laboratories: A valuable reagent for methodological development in cross-coupling chemistry and the exploration of new synthetic pathways.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale synthesis due to its defined structure and reactivity profile.

Basic Information

Product Name	2-((1,4-Dioxaspiro[4.5]decan-8-ylidene)methyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.	2246878-23-7
Molecular Formula	C₁₈H₂₉BO₄
Molecular Weight	320.23 g/mol
Synonyms	2-[(1,4-Dioxaspiro[4.5]dec-8-ylidene)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Spirocyclic Boronic Ester Pinacol Ester; 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ylmethylene)-1,4-dioxaspiro[4.5]decane; (1,4-Dioxaspiro[4.5]dec-8-ylidenemethyl)boronic acid pinacol ester; Spiro[4.5]decane-8-carbaldehyde ethylene acetal-derived pinacol boronate; CAS 2246878-23-7
EINECS	Contact for details

Quality Control

Our production of this boronic ester adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
¹H NMR	Conforms to structure
¹¹B NMR	Conforms to structure
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.