Description

2-[4-(4-Fluoro-2-Methylbenzyloxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity, advanced pharmaceutical intermediate belonging to the class of pinacol boronic esters. This compound is a critical building block in modern synthetic chemistry, enabling the precise construction of complex molecules through cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures, which are common motifs in drug discovery.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require specific fluorinated aromatic components.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the creation of molecular probes for diagnostic and imaging applications.

Basic Information

Product Name	2-[4-(4-Fluoro-2-Methylbenzyloxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	2246843-54-7
Molecular Formula	C20H24BFO3
Molecular Weight	342.22 g/mol
Synonyms	4-(4-Fluoro-2-methylbenzyloxy)phenylboronic acid pinacol ester; 2-[4-[(4-Fluoro-2-methylphenyl)methoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-((4-Fluoro-2-methylbenzyl)oxy)phenyl)boronic acid pinacol ester; 4-(4-Fluoro-2-methylbenzyloxy)benzeneboronic acid pinacol ester; 4-Fluoro-2-methylbenzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl ether; CAS 2246843-54-7
EINECS	Contact for details

Quality Control

Our 2-[4-(4-Fluoro-2-Methylbenzyloxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.