Description

n-(2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Isobutyramide is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel small molecule therapeutics, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring complex biaryl structures.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds under mild conditions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate aromatic boronate motifs.
• Material Science: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and sensors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Facilitates the modular assembly of bifunctional molecules for targeted protein degradation research.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening in drug discovery campaigns.

Basic Information

Product Name	n-(2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Isobutyramide
CAS No.	2246834-15-9
Molecular Formula	C17H26BNO3
Molecular Weight	303.21 g/mol
Synonyms	2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-isobutyrylaniline; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-N-(2-methylpropyl)benzamide; Isobutyramide, N-[2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Pinacol ester of [3-(Isobutyrylamino)-4-methylphenyl]boronic acid; 2246834-15-9; Aryl Boronic Ester Pinacol; Boronate Ester Intermediate.
EINECS	Contact for details

Quality Control

Our n-(2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Isobutyramide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.