Description

1,3,2-Dioxaborolane, 2-(Cyclobutylidenemethyl)-4,4,5,5-Tetramethyl- is a specialized organoboron reagent featuring a reactive cyclobutylidene methylene unit. This compound matters as a versatile building block for introducing the cyclobutylidene moiety in advanced synthetic chemistry, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and material science.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key precursor for palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, essential for synthesizing complex organic molecules.
• Pharmaceutical Intermediate: Used in the research and development of novel active pharmaceutical ingredients (APIs), particularly for creating strained ring systems.
• Agrochemical Synthesis: Serves as a building block in the creation of new herbicides, fungicides, and insecticides with potentially enhanced activity.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Ligand and Catalyst Development: Useful for synthesizing novel boron-containing ligands for transition metal catalysis.
• Chemical Biology Probes: Can be utilized to create tagged molecules for studying biological processes and protein interactions.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-(Cyclobutylidenemethyl)-4,4,5,5-Tetramethyl-
CAS No.	2246816-47-5
Molecular Formula	C13H21BO2
Molecular Weight	220.12 g/mol
Synonyms	2-(Cyclobutylidenemethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Cyclobutylidenemethylboronic acid pinacol ester; (Cyclobutylidenemethyl)boronic acid pinacol ester; Cyclobutylidenemethyl-Bpin; 2-(Cyclobutylidenmethyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; B-(Cyclobutylidenemethyl)pinacolborane; Cyclobutylmethylidene boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-(Cyclobutylidenemethyl)-4,4,5,5-Tetramethyl- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We adhere to ISO 9001 quality management principles, and our analytical methods include NMR, HPLC, and GC to verify specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.