Description

1,3,2-Dioxaborolane, 2-[3-[(2-Fluorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl- is a high-purity, advanced boronic ester derivative, specifically designed as a critical synthetic intermediate. Its value lies in providing a protected boronic acid functionality that is stable to purification and storage, enabling efficient cross-coupling reactions. This compound is essential for researchers and manufacturers in pharmaceutical development and advanced material science, particularly for constructing complex biaryl structures. The CAS number for this product is 2246811-02-7.

Application

This specialized boronic ester is a key building block in modern synthetic chemistry, primarily serving as a precursor in cross-coupling reactions.

• Suzuki-Miyaura Cross-Coupling Reactions: As a stable, air-tolerant alternative to boronic acids, it is used to form carbon-carbon bonds in the synthesis of complex organic molecules.
• Pharmaceutical Intermediate: Critical for the research and development of active pharmaceutical ingredients (APIs), especially those containing fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel ligands and organometallic catalysts.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is crucial.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for biological target identification and study.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[3-[(2-Fluorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	2246811-02-7
Molecular Formula	C19H22BFO3
Molecular Weight	328.19 g/mol
Synonyms	2-(3-((2-Fluorobenzyl)oxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [3-[(2-Fluorophenyl)methoxy]phenyl]boronic acid pinacol ester; 3-[(2-Fluorobenzyl)oxy]phenylboronic acid pinacol ester; (3-((2-Fluorobenzyl)oxy)phenyl)boronic acid pinacol ester; 2-Fluorobenzyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl ether; PINACOL [3-[(2-FLUOROBENZYL)OXY]PHENYL]BORONATE
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.