Description

1-Azetidinecarboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique azetidine ring system coupled with a pinacol boronate ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions like Suzuki-Miyaura. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for the discovery and development of new therapeutic agents, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting proteases and other enzymatic pathways.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety makes it an ideal reagent for forming carbon-carbon bonds, a fundamental step in constructing complex organic molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical spaces and improve drug potency and selectivity.
• Bioconjugation & Probe Development: Can be utilized to create chemical probes for studying biological processes and target engagement within cells.
• Process Chemistry & Scale-Up: Supports the development of efficient and scalable synthetic routes for active pharmaceutical ingredients (APIs) under GMP-like conditions.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in cutting-edge synthetic organic chemistry projects.

Basic Information

Product Name	1-Azetidinecarboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester
CAS No.	2246802-17-3
Molecular Formula	C15H26BNO4
Molecular Weight	295.19 g/mol
Synonyms	tert-Butyl 3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]azetidine-1-carboxylate; 1-Boc-3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]azetidine; 3-[(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]azetidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-methyleneazetidine pinacol boronic ester; Azetidine-1-carboxylic acid, 3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]-, 1,1-dimethylethyl ester; Boc-Azetidine-3-methylene-Bpin
EINECS	Contact for details

Quality Control

Our production of 1-Azetidinecarboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research and development applications. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to verify identity, purity, and the absence of critical impurities. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.