Description

n-(2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxamide is a high-value, advanced pharmaceutical intermediate featuring a cyclopropane carboxamide core and a protected boronic ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for constructing biaryl and heterobiaryl structures in drug discovery.
• Pharmaceutical Intermediate: Used in the synthesis of complex, target-specific molecules for preclinical and clinical research.
• Medicinal Chemistry Research: A versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Can be utilized as a linker component or warhead in the design of targeted protein degraders.
• Agrochemical Research: Potential intermediate in the development of new active ingredients with novel modes of action.
• Material Science: Investigated as a monomer or precursor for advanced polymeric materials with specific electronic or structural properties.

Basic Information

Product Name	n-(2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxamide
CAS No.	2246786-07-0
Molecular Formula	C₁₆H₂₁BClNO₃
Molecular Weight	321.61 g/mol
Synonyms	2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopropylbenzamide; Cyclopropanecarboxamide, N-[2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; N-Cyclopropyl-2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; CAS 2246786-07-0; 2-Chloro-5-(pinacolatoboryl)-N-cyclopropylbenzamide; (2-Chloro-5-(N-cyclopropylcarbamoyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines for advanced intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.