Description

Benzonitrile, 2-[[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]Methyl]- is a high-value, functionalized aromatic nitrile containing a pinacol boronate ester group, making it a versatile advanced pharmaceutical intermediate and key building block for modern synthetic chemistry. This compound is specifically engineered for applications in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for carbon-carbon bond formation. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and materials science who require reliable, high-purity precursors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing biaryl or extended aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aromatic frameworks.
• Material Science: Serves as a monomer or precursor for organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Chemical Research & Development: An indispensable reagent in medicinal chemistry and process R&D for exploring new chemical entities via palladium-catalyzed cross-coupling.
• Ligand and Catalyst Development: Used to synthesize novel ligands and complex organic molecules for catalytic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.

Basic Information

Item	Details
Product Name	Benzonitrile, 2-[[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]Methyl]-
CAS No.	2246772-09-6
Molecular Formula	C20H22BNO3
Molecular Weight	335.21 g/mol
Synonyms	2-((3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)methyl)benzonitrile; (3-(2-Cyanobenzyloxy)phenyl)boronic acid pinacol ester; 2-[[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl]benzonitrile; Boronic ester derivative of benzonitrile; Aryl boronate ester intermediate; Suzuki coupling reagent
EINECS	Contact for details

Quality Control

Every batch of Benzonitrile, 2-[[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]Methyl]- is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including NMR (1H, 13C, 11B), HPLC, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.