Description

n-(2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-2-Methoxyacetamide is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring aryl-aryl bond formation.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air-tolerant boronic ester reagent for palladium-catalyzed coupling with aryl halides.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Chemical Biology & Proteomics: Can be utilized as a molecular probe or linker in bioconjugation strategies.
• Academic & Contract Research: Essential for synthetic chemistry research in universities and CROs (Contract Research Organizations).

Basic Information

Product Name	n-(2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-2-Methoxyacetamide
CAS No.	2246751-94-8
Molecular Formula	C15H21BClNO4
Molecular Weight	325.59 g/mol
Synonyms	2-Methoxy-N-[2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 2-Methoxyacetamide; 2246751-94-8; 2-Methoxy-N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide; Boronic ester intermediate CAS 2246751-94-8; Pinacol ester of (5-Acetamido-2-chlorophenyl)boronic acid
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-2-Methoxyacetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.