Description

Cyclopropanecarboxamide, N-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]- is a high-value, advanced pharmaceutical intermediate featuring a cyclopropane carboxamide moiety linked to a pinacol boronate ester. This compound matters for its critical role as a versatile building block in modern synthetic chemistry, enabling key carbon-carbon and carbon-heteroatom bond-forming reactions. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry for drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing cyclopropane rings.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group makes it an excellent reagent for palladium-catalyzed cross-coupling, a fundamental reaction for constructing complex biaryl and heteroaryl structures in drug molecules.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides with potentially improved efficacy and environmental profiles.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where the cyclopropane unit can influence electronic properties.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways within cells.

Basic Information

Product Name	Cyclopropanecarboxamide, N-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]-
CAS No.	2246743-13-3
Molecular Formula	C16H22BNO3
Molecular Weight	287.16 g/mol
Synonyms	N-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxamide; 2-Cyclopropanecarboxamidophenylboronic acid pinacol ester; Cyclopropanecarboxylic acid [2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-amide; B-[2-(Cyclopropanecarboxamido)phenyl]boronic acid pinacol ester; 2246743-13-3; Cyclopropanamide, N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxamide, N-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.