Description

1,3,2-Dioxaborolane, 2-(2,6-Difluoro-3-Methylphenyl)-4,4,5,5-Tetramethyl- is a high-purity, advanced boronic ester derivative, serving as a critical synthetic intermediate. Its value lies in enabling precise carbon-carbon and carbon-heteroatom bond formation, which is fundamental for constructing complex molecular architectures. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it facilitates the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, contributing to the development of compounds with improved efficacy and environmental profiles.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and activity-based protein profiling (ABPP) reagents.
• Ligand & Catalyst Development: Serves as a precursor for creating novel boron-containing ligands and catalysts for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the global life sciences industry.

Basic Information

Item	Details
Product Name	1,3,2-Dioxaborolane, 2-(2,6-Difluoro-3-Methylphenyl)-4,4,5,5-Tetramethyl-
CAS No.	2246738-41-8
Molecular Formula	C15H21BFO2
Molecular Weight	278.14 g/mol
Synonyms	2-(2,6-Difluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2,6-Difluoro-3-methylphenyl)boronic acid pinacol ester; 2,6-Difluoro-3-methylbenzeneboronic acid pinacol ester; 2,6-Difluoro-m-tolylboronic acid pinacol ester; 2-(2,6-Difluoro-3-methylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; Pinacol (2,6-difluoro-3-methylphenyl)boronate; (2,6-Difluoro-3-methylphenyl)BPin
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-(2,6-Difluoro-3-Methylphenyl)-4,4,5,5-Tetramethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and lot-to-lot consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and during weighing to prevent hydrolysis and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.