Description

1,3,2-Dioxaborolane, 2-[3-[(2,4-Dichlorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl is a high-purity, pinacol-protected boronic ester derivative, a critical intermediate in modern synthetic chemistry. Its value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for compounds containing biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific phenyl-boronate coupling steps.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, including polymers for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and sensors that utilize boronate ester chemistry for detection and labeling.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds with high fidelity and functional group tolerance.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[3-[(2,4-Dichlorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl
CAS No.	2246728-07-2
Molecular Formula	C19H21BCl2O3
Molecular Weight	391.09 g/mol
Synonyms	[3-[(2,4-Dichlorophenoxy)methyl]phenyl]boronic acid pinacol ester; 2-[3-[(2,4-Dichlorophenoxy)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-[(2,4-Dichlorophenoxy)methyl]benzeneboronic acid pinacol ester; (3-((2,4-Dichlorophenoxy)methyl)phenyl)boronic acid pinacol ester; Pinacol [3-[(2,4-dichlorophenoxy)methyl]phenyl]boronate; Boronic acid, B-[3-[(2,4-dichlorophenoxy)methyl]phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-[3-[(2,4-Dichlorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent performance for sensitive synthetic applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.