Description

n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propionamide is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound matters as a critical building block in modern synthetic chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction for constructing complex carbon-carbon bonds. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS research.
• Suzuki-Miyaura Cross-Coupling: Enables the efficient formation of biaryl and other C-C bonds in complex molecule assembly.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a precursor for organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Chemical Biology & Proteomics: Can be utilized as a probe or linker in bioconjugation and target identification studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds at various scales.

Basic Information

Product Name	n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propionamide
CAS No.	2246698-15-5
Molecular Formula	C15H22BNO3
Molecular Weight	275.15 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-propionylaniline; N-Propionyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 4-(Pinacolatoboryl)phenylpropionamide; 4-Propionamidophenylboronic acid pinacol ester; 2246698-15-5; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenepropanamide
EINECS	Contact for details

Quality Control

Our n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propionamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.