Description

2-Methoxy-n-(2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critically important for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. It is primarily required by R&D and process development teams in the pharmaceutical and agrochemical industries for the efficient synthesis of complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex aryl-aryl linkages.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and bioconjugation reagents for target identification and biomarker studies.
• Academic & Industrial R&D: A versatile reagent for methodological development in palladium-catalyzed cross-coupling reactions and library synthesis for high-throughput screening.

Basic Information

Product Name	2-Methoxy-n-(2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide
CAS No.	2246691-80-3
Molecular Formula	C₁₈H₂₈BNO₄
Molecular Weight	333.24 g/mol
Synonyms	2-Methoxy-N-[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline Acetamide Derivative; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylphenyl 2-Methoxyacetamide; Boronic acid, B-[4-[(2-methoxyacetyl)amino]-3-methylphenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Methoxy-n-(2-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.