Description

Propanamide, 2-Methyl-n-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is a high-purity, advanced pharmaceutical intermediate featuring a unique boronic ester-protected aniline moiety. This compound is specifically engineered for use in sophisticated cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and materials science. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, agrochemical synthesis, and the development of organic electronic materials who require reliable, high-quality precursors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring biaryl linkages.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a key organoboron component for forming carbon-carbon bonds in complex organic synthesis.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the development of organic light-emitting diodes (OLEDs), semiconductors, and conductive polymers.
• Chemical Biology & Proteomics: Acts as a building block for creating molecular probes and activity-based protein profiling reagents.
• Academic & Industrial R&D: A valuable tool for chemists in university laboratories and corporate research centers exploring new synthetic methodologies.

Basic Information

Item	Details
Product Name	Propanamide, 2-Methyl-n-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-
CAS No.	2246676-49-1
Molecular Formula	C16H24BNO3
Molecular Weight	289.18 g/mol
Synonyms	2-Methyl-N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanamide; N-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)isobutyramide; 2-Methyl-N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanamide; Isobutyramide, N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Boronic acid, B-[2-[(2-methyl-1-oxopropyl)amino]phenyl]-, 1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Every batch of Propanamide, 2-Methyl-n-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity, and impurity profile. Our quality protocols are designed to support cGMP and ISO-guided production environments.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.