Description

n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclobutanecarboxamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group, which is critical for modern synthetic methodologies. This compound matters because it serves as a key building block in the synthesis of complex molecules, enabling efficient carbon-carbon bond formation through Suzuki-Miyaura cross-coupling reactions. Pharmaceutical R&D teams and fine chemical manufacturers need it for developing novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety acts as a stable, handle for palladium-catalyzed coupling with aryl/vinyl halides, enabling efficient construction of biaryl structures.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for commercial drug manufacturing.
• Agrochemical Research: Serves as a building block for developing new crop protection agents and herbicides with complex aromatic backbones.
• Material Science: Potential use in the synthesis of organic electronic materials, such as polymers for OLEDs, where precise aryl-aryl linkages are required.

Basic Information

Product Name	n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclobutanecarboxamide
CAS No.	2246657-11-2
Molecular Formula	C17H24BNO3
Molecular Weight	301.19 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclobutylbenzamide; Cyclobutanecarboxamide, N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; N-Cyclobutyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 2-(N-Cyclobutylcarboxamido)phenylboronic acid pinacol ester; Aryl Boronate Ester Intermediate 2246657-11-2; Benzamide, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclobutyl-
EINECS	Contact for details

Quality Control

Our n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclobutanecarboxamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Products undergo rigorous quality testing, including HPLC, NMR, and MS, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support development with custom purity grades and analytical method development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) in a desiccated environment to prevent hydrolysis of the boronate ester. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.