Description

1,3,2-Dioxaborolane, 2-[(4,4-Difluorocyclohexylidene)Methyl]-4,4,5,5-Tetramethyl- is a high-value, advanced boronic ester derivative featuring a unique difluorocyclohexylidene scaffold. This compound is a critical building block in modern synthetic chemistry, prized for its stability and reactivity in cross-coupling reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for constructing complex biaryl and heteroaryl structures in drug discovery and development.
• Agrochemical Synthesis: Used in the synthesis of advanced crop protection agents, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Materials Science Research: Serves as a monomer or functionalization agent in the development of novel organic electronic materials, liquid crystals, and polymers.
• Chemical Biology Probes: Employed in the synthesis of boronic acid-based probes and sensors for detecting sugars, peroxides, and other analytes.
• Process Chemistry: Utilized in scalable manufacturing routes for active pharmaceutical ingredients (APIs) requiring the specific difluorocyclohexyl moiety.
• Academic & Industrial R&D: A versatile reagent for methodology development and exploring new chemical space in organoboron chemistry.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[(4,4-Difluorocyclohexylidene)Methyl]-4,4,5,5-Tetramethyl-
CAS No.	2246650-11-1
Molecular Formula	C13H21B1F2O2
Molecular Weight	258.12 g/mol
Synonyms	2-[(4,4-Difluorocyclohexylidene)Methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-((4,4-difluorocyclohexylidene)methyl)-1,3,2-dioxaborolane; (4,4-Difluorocyclohexylidene)methylboronic acid pinacol ester; (4,4-Difluorocyclohexylmethylidene)boronic acid pinacol ester; Difluorocyclohexyl Methylene Boronic Acid Pinacol Ester; Pinacol (4,4-Difluorocyclohexylidene)methylboronate
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F), HPLC, and GC analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in GMP-intermediate and high-purity research contexts.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.