Description

n-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Butanamide is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester moiety acts as a stable, air-tolerant reagent for palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Medicinal Chemistry Research: Enables rapid analog synthesis and structure-activity relationship (SAR) studies in drug discovery pipelines.
• Pre-clinical Development: Used to produce gram to kilogram quantities of lead compounds for pharmacological and toxicological evaluation.
• Ligand and Material Science: Potential precursor for creating functional organic materials or metal-organic complexes.

Basic Information

Product Name	n-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Butanamide
CAS No.	2246646-52-4
Molecular Formula	C16H24BNO3
Molecular Weight	289.18 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenebutanamide; N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butyramide; 2-(4-Butyramidophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Butanamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 2246646-52-4; Pinacol [4-(Butyrylamino)phenyl]boronate
EINECS	Contact for details

Quality Control

Our n-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Butanamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and residual solvent levels are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.