Description

2-(4-((4-Bromo-2-Fluorophenoxy)Methyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for developing new active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, including herbicides and fungicides.
• Material Science Research: Serves as a monomer or building block for developing organic electronic materials, such as OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of complex ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized to create labeled compounds and probes for studying biological pathways and target engagement.
• Custom Synthesis: A versatile starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	2-(4-((4-Bromo-2-Fluorophenoxy)Methyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2246646-40-0
Molecular Formula	C19H21BBrFO3
Molecular Weight	422.08 g/mol
Synonyms	4-Bromo-2-fluoro-4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzhydryl ether; 2-[4-[(4-Bromo-2-fluorophenoxy)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-((4-Bromo-2-fluorophenoxy)methyl)phenyl)boronic acid pinacol ester; 4-Bromo-2-fluorobenzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl ether; Bromo-fluoro phenyloxymethyl phenyl boronic ester; CAS 2246646-40-0; Pinacol boronate ester intermediate
EINECS	Contact for details

Quality Control

Our 2-(4-((4-Bromo-2-Fluorophenoxy)Methyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with relevant regulatory frameworks for pharmaceutical development (e.g., ICH Q7, GMP where applicable).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.