Description

1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[2-[(4-Methylphenyl)Methoxy]Phenyl]- is a sophisticated organoboron reagent, specifically a pinacol boronic ester derivative, designed for advanced synthetic chemistry. This compound is a critical building block in cross-coupling reactions, enabling the efficient and selective formation of carbon-carbon bonds. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require high-purity, functionalized intermediates for complex molecule synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for palladium-catalyzed coupling with aryl/vinyl halides to construct biaryl and conjugated systems.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for constructing complex aromatic and heteroaromatic scaffolds.
• Agrochemical Product Development: Serves as a precursor in the synthesis of novel herbicides, fungicides, and insecticides that require specific aryl motifs.
• Materials Science & OLED Development: Employed in the synthesis of organic semiconductors, light-emitting materials, and other advanced functional materials.
• Polymer Chemistry: Can be utilized to introduce boronic ester functional groups into polymer backbones or side chains for further modification.
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for diagnostic applications.

Basic Information

Product Name	1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[2-[(4-Methylphenyl)Methoxy]Phenyl]-
CAS No.	2246645-45-2
Molecular Formula	C20H25BO3
Molecular Weight	324.22 g/mol
Synonyms	2-[(4-Methylphenoxy)methyl]phenylboronic acid pinacol ester; [2-[(4-Methylbenzyl)oxy]phenyl]boronic acid pinacol ester; 2-[(p-Tolylmethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-{[(4-Methylphenyl)methoxy]phenyl})boronic acid pinacol ester; Pinacol [2-[(4-methylbenzyl)oxy]phenyl]boronate
EINECS	Contact for details

Quality Control

Our high-purity organoboron reagents are manufactured under strict quality control protocols to ensure batch-to-batch consistency and optimal performance in sensitive coupling reactions. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to verify chemical identity, purity, and the absence of critical impurities like palladium. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage and when dispensing to prevent hydrolysis and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.