Description

2-(3-((3,5-Difluorobenzyl)Oxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a key Suzuki-Miyaura cross-coupling reagent, enabling the efficient construction of complex biaryl structures essential for advanced materials and pharmaceuticals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex biaryl or heterobiaryl motifs for oncology, CNS, and antiviral therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures for enhanced activity and selectivity.
• Material Science Research: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials (OLEDs, OFETs) where the difluorobenzyloxy phenyl unit imparts specific electronic or physical properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for imaging and diagnostic applications, leveraging the boronate functionality for further bioconjugation.
• Catalyst Ligand Precursor: Can be utilized to synthesize novel ligand frameworks for transition metal catalysis in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-(3-((3,5-Difluorobenzyl)Oxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2246637-22-7
Molecular Formula	C19H21BF2O3
Molecular Weight	346.18 g/mol
Synonyms	3-((3,5-Difluorobenzyl)oxy)phenylboronic acid pinacol ester; (3-((3,5-Difluorobenzyl)oxy)phenyl)boronic acid pinacol ester; 2-[3-[(3,5-Difluorophenyl)methoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-((3,5-Difluorobenzyl)oxy)benzeneboronic acid pinacol ester; Pinacol [3-((3,5-difluorobenzyl)oxy)phenyl]boronate; B-[3-[(3,5-Difluorophenyl)methoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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Quality Control

Our 2-(3-((3,5-Difluorobenzyl)Oxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from oxidizing agents and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.