Description

n-(4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pivalamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling the efficient synthesis of complex molecules through key cross-coupling reactions. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl structures in drug discovery pipelines.
• Pharmaceutical Intermediate: Serves as a versatile building block in the synthesis of potential therapeutic agents, including kinase inhibitors and other small molecule drugs.
• Agrochemical Synthesis: Used in the research and development of novel crop protection agents and herbicides.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs and semiconductors.
• Chemical Biology & Proteolysis-Targeting Chimeras (PROTACs): Utilized as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP and non-GMP production of complex organic molecules.

Basic Information

Product Name	n-(4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pivalamide
CAS No.	2246631-55-8
Molecular Formula	C18H28BNO3
Molecular Weight	317.24 g/mol
Synonyms	Pivalamide, N-[4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 2-Methyl-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylphenyl]propanamide; 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl Pivalamide; 2246631-55-8; 3-Pivalamido-4-methylphenylboronic acid pinacol ester; N-(3-Borono-4-methylphenyl)pivalamide pinacol ester
EINECS	Contact for details

Quality Control

Our n-(4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pivalamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee supply reliability and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.