Description

2-(2-((5-Bromo-2-Methylphenoxy)Methyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its core value lies in its role as a key pinacol boronate ester, enabling critical Suzuki-Miyaura cross-coupling reactions to construct complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules. The CAS number for this compound is 2246589-58-0.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing complex biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific bromo-methylphenoxy architectures.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its boronate functionality.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a stable, reactive partner in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds efficiently.
• Chemical Biology & Medicinal Chemistry: Utilized in the discovery and optimization of drug-like compounds for high-throughput screening and structure-activity relationship (SAR) studies.
• Ligand & Catalyst Development: Acts as a precursor for synthesizing specialized ligands or functionalized molecules used in catalytic systems.

Basic Information

Product Name	2-(2-((5-Bromo-2-Methylphenoxy)Methyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2246589-58-0
Molecular Formula	C20H24BBrO3
Molecular Weight	403.12 g/mol
Synonyms	5-Bromo-2-methylphenyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl ether; 2-[(5-Bromo-2-methylphenoxy)methyl]phenylboronic acid pinacol ester; (2-((5-Bromo-o-tolyloxy)methyl)phenyl)boronic acid pinacol ester; 2-(2-((5-Bromo-2-methylphenoxy)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[2-[[(5-bromo-2-methylphenyl)oxy]methyl]phenyl]-, 1,1-dimethylethyl ester; CAS 2246589-58-0; Pinacol (2-((5-bromo-2-methylphenoxy)methyl)phenyl)boronate
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Quality Control

Our 2-(2-((5-Bromo-2-Methylphenoxy)Methyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.