Description

tert-Butyl 2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4H,6H,7H-Thieno[3,2-C]Pyridine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a fused thienopyridine core and a protected boronic ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery programs.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a key boron-containing partner in Pd-catalyzed cross-couplings for constructing C-C bonds in drug candidate libraries.
• Pharmaceutical Intermediate: An essential precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization stages to explore structure-activity relationships (SAR) around the thienopyridine scaffold.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the synthesis of heterobifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Facilitates the creation of labeled compounds for studying biological mechanisms and target engagement.
• Agrochemical Synthesis: Potential intermediate for developing novel crop protection agents with unique modes of action.
• Material Science: Can be investigated as a monomer or precursor for organic electronic materials due to its conjugated system.

Basic Information

Product Name	tert-Butyl 2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4H,6H,7H-Thieno[3,2-C]Pyridine-5-Carboxylate
CAS No.	2246556-84-1
Molecular Formula	C21H30BNO4S
Molecular Weight	403.34 g/mol
Synonyms	5-tert-Butoxycarbonyl-4,7-dihydro-6H-thieno[3,2-c]pyridine-2-boronic acid pinacol ester; tert-Butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carboxylic acid tert-butyl ester; BTR-Thienopyridine-Bpin; Thieno[3,2-c]pyridine-2-boronic acid pinacol ester, 5-tert-butoxycarbonyl-4,5,6,7-tetrahydro-; CAS 2246556-84-1
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4H,6H,7H-Thieno[3,2-C]Pyridine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.