Description

Thalidomide-o-Amido-Peg4-C2-Nh2 Hydrochloride is a high-purity, functionalized PEG linker derivative of thalidomide, designed for advanced bioconjugation and pharmaceutical research. This compound is critical for the development of Proteolysis-Targeting Chimeras (PROTACs) and other targeted protein degradation therapeutics, enabling precise control over drug delivery and efficacy. It is an essential building block for researchers and developers in the fields of oncology, immunology, and chemical biology who require reliable, well-characterized intermediates for novel drug discovery programs.

Application

• PROTAC Linker Synthesis: A key component for constructing heterobifunctional molecules that recruit E3 ubiquitin ligases to degrade target proteins.
• Anticancer Drug Development: Used in the research and development of next-generation targeted cancer therapies, particularly for hematological malignancies and solid tumors.
• Bioconjugation Reagent: Facilitates the attachment of thalidomide-based ligands to antibodies, peptides, or small molecules to create antibody-drug conjugates (ADCs) or other targeted delivery systems.
• Chemical Biology Probes: Serves as a tool compound for studying cereblon (CRBN)-mediated protein degradation pathways and related biological mechanisms.
• Pharmaceutical Intermediate: Employed in the scalable synthesis of clinical candidates for immunomodulatory and anti-angiogenic applications.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focused on protein homeostasis and novel therapeutic modalities.

Basic Information

Product Name	Thalidomide-o-Amido-Peg4-C2-Nh2 Hydrochloride
CAS No.	2245697-85-0
Molecular Formula	C31H43ClN4O11
Molecular Weight	683.15 g/mol
Synonyms	Thalidomide-PEG4-C2-NH2 HCl; (S)-2-(2-(2-(2-(2-(2-(4-(1-Oxo-3-(1,3-dioxoisoindolin-2-yl)-2,3-dihydro-1H-isoindol-2-yl)butanamido)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)acetic acid hydrochloride; Thalidomide-O-amido-PEG4-C2-amine hydrochloride; CRBN Ligand-Linker Conjugate 7; E3 Ligase Ligand-Linker Conjugate; Amin-PEG4-VA-Thalidomide HCl; Thalidomide-based PROTAC Linker HCl Salt
EINECS	Contact for details

Quality Control

Our Thalidomide-o-Amido-Peg4-C2-Nh2 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay purity, chiral purity, and residual solvent levels to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the material should be handled in a dry environment and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% ee (S-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.