Description

2-(5-Bromo-[1,1'-Biphenyl]-3-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, specifically in Suzuki-Miyaura cross-coupling reactions, which are fundamental to constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who are developing novel active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific biphenyl structures.
• Material Science Research: Building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(5-Bromo-[1,1'-Biphenyl]-3-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2244251-87-2
Molecular Formula	C24H28BBrO2
Molecular Weight	439.20 g/mol
Synonyms	5-Bromo-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,1'-biphenyl; 2-(5-Bromo-3-biphenylyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-Bromo-[1,1'-biphenyl]-3-yl)boronic acid pinacol ester; 3-Bromo-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl; 5-Bromo-3'-(pinacolatoboryl)-1,1'-biphenyl; Biphenyl-3-boronic acid, 5-bromo-, pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(5-Bromo-[1,1'-Biphenyl]-3-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. We are committed to meeting the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.