Description

2-(3,3-Difluorocyclobutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a versatile intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for introducing the difluorocyclobutyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring a difluorocyclobutyl group for metabolic stability or binding affinity.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the cyclobutyl ring system is desired.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, via cross-coupling polymerization.
• Chemical Biology & Medicinal Chemistry: Serves as a probe or precursor in the synthesis of bioactive molecules for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CROs/CMOs developing proprietary compounds for clients.
• Academic Research: Used in university and institutional labs for methodological development in organoboron chemistry and catalysis.

Basic Information

Product Name	2-(3,3-Difluorocyclobutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.	2243345-24-4
Molecular Formula	C10H17B1F2O2
Molecular Weight	214.05 g/mol
Synonyms	(3,3-Difluorocyclobutyl)boronic acid pinacol ester; (3,3-Difluorocyclobutyl)boronic acid, pinacol ester; 2-(3,3-Difluorocyclobutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3,3-Difluorocyclobutane-1-boronic acid pinacol ester; Pinacol (3,3-difluorocyclobutyl)boronate; (3,3-Difluorocyclobutyl)-Bpin; B-(3,3-Difluorocyclobutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(3,3-Difluorocyclobutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC, and GC analysis, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.