Description

4,4,5,5-Tetramethyl-2-(4-(Methyl-D3)Phenyl)-1,3,2-Dioxaborolane is a high-purity, deuterated boronic ester derivative, specifically designed for advanced synthetic and analytical applications. This compound is valued for its role as a stable, protected boronic acid equivalent, crucial for precise cross-coupling reactions and isotopic labeling studies. It is primarily sought by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing novel compounds and conducting metabolic research.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing complex, deuterium-labeled drug candidates and active pharmaceutical ingredients (APIs).
• Isotope Labeling: Serves as a source of deuterium (D3-methyl group) for the synthesis of internal standards used in mass spectrometry-based bioanalytical assays and pharmacokinetic studies.
• Agrochemical Research: Used in the development of novel, labeled pesticides and herbicides to study environmental fate, metabolism, and degradation pathways.
• Material Science: A precursor for creating deuterated organic electronic materials, such as those used in OLEDs and organic photovoltaics, to study charge transport and stability.
• Chemical Biology: Employed in probe and tracer molecule synthesis for mechanistic studies and imaging applications.
• Process Chemistry: Utilized in route scouting and optimization for scalable, efficient synthesis of deuterated target molecules.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(4-(Methyl-D3)Phenyl)-1,3,2-Dioxaborolane
CAS No.	2235417-07-7
Molecular Formula	C13H18D3BO2
Molecular Weight	219.15 g/mol
Synonyms	4-(Methyl-d3)phenylboronic acid pinacol ester; (4-(Trideuteriomethyl)phenyl)boronic acid pinacol ester; 2-(4-(Methyl-d3)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (4-(Trideuteriomethyl)phenyl)boronate; Deuterated MethylphenylBPin; d3-MethylphenylBPin; 4-(CD3)C6H4Bpin
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(4-(Methyl-D3)Phenyl)-1,3,2-Dioxaborolane is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (D%), and impurity profiles. We adhere to relevant industry standards for fine chemical and labeled compound production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain product integrity and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.