Description

Quinoline, 8-Fluoro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate and a versatile building block for Suzuki-Miyaura cross-coupling reactions. Its core value lies in enabling the efficient synthesis of complex fluorinated quinoline derivatives, which are crucial scaffolds in modern drug discovery. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate the unique properties of fluorine into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor for synthesizing active pharmaceutical ingredients (APIs) containing fluorinated quinoline motifs, particularly in oncology, anti-infective, and CNS drug candidates.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a critical boron-containing partner for palladium-catalyzed cross-coupling to form biaryl and heterobiaryl structures, a cornerstone reaction in medicinal chemistry.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the fluorinated quinoline structure can enhance biological activity and environmental stability.
• Organic Light-Emitting Diode (OLED) Materials: Acts as a building block for electron-transport or host materials in OLED devices, leveraging the electron-deficient nature of the quinoline core.
• Ligand Synthesis for Catalysis: Employed in the preparation of novel nitrogen-containing ligands for transition metal catalysts used in asymmetric synthesis.
• Fluorescent Probe & Sensor Development: Utilized to create fluorophores and chemosensors for bioimaging and diagnostic applications due to the tunable photophysical properties of the quinoline scaffold.

Basic Information

Product Name	Quinoline, 8-Fluoro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	2235386-14-6
Molecular Formula	C₁₉H₂₀BFNO₂
Molecular Weight	315.18 g/mol
Synonyms	8-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-fluoroquinoline; 8-Fluoroquinoline-6-boronic acid pinacol ester; 8-Fluoro-6-quinolineboronic acid pinacol ester; (8-Fluoro-6-quinolinyl)boronic acid pinacol ester; Quin-6-Boronic Acid, 8-Fluoro-, Pinacol Ester; 8-Fluoro-6-(pinacolatoboryl)quinoline
EINECS	Contact for details

Quality Control

Our Quinoline, 8-Fluoro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place, ideally at 2-8°C for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.