Description

(2R)-2-(Difluoromethyl)Azetidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant interest in modern synthetic chemistry. Its value lies in the unique azetidine scaffold and difluoromethyl group, which are critical motifs for modulating the pharmacokinetic and metabolic properties of bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Proteolysis Targeting Chimera (PROTAC) Development: Incorporated as a linker or warhead component in bifunctional degrader molecules.
• Agrochemical Synthesis: Acts as a building block for advanced crop protection agents requiring specific stereochemistry.
• Ligand and Catalyst Development: Utilized in the preparation of chiral ligands for asymmetric catalysis.
• Chemical Biology Probes: Employed in the design of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	(2R)-2-(Difluoromethyl)Azetidine Hydrochloride
CAS No.	2231665-58-8
Molecular Formula	C4H8ClF2N
Molecular Weight	151.56 g/mol
Synonyms	(R)-2-(Difluoromethyl)azetidine hydrochloride; (2R)-2-(Difluoromethyl)azetidine HCl; Azetidine, 2-(difluoromethyl)-, hydrochloride, (2R)-; (R)-2-(Difluoromethyl)azetidine hydrochloride salt; (R)-2-(Difluoromethyl)azetidinium chloride; (2R)-2-(Difluoromethyl)-1-azetidinium chloride; (R)-Azetidine-2-(difluoromethyl) hydrochloride
EINECS	Contact for details

Quality Control

Our (2R)-2-(Difluoromethyl)Azetidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.