Description

trans-3-Hydroxy-3-Methylcyclobutane-1-Methamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 2231664-53-0. This compound is valued for its unique cyclobutane scaffold, which is increasingly important in modern medicinal chemistry for creating novel bioactive molecules with improved metabolic profiles. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in areas requiring constrained, three-dimensional molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational rigidity into drug candidates.
• Peptidomimetics: Serves as a constrained, non-natural amino acid analog for the development of peptide-based therapeutics with enhanced stability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Synthesis: Potential intermediate for creating novel herbicides or fungicides with new modes of action.
• Material Science: Can be investigated as a monomer or cross-linking agent for specialty polymers with unique thermal or mechanical properties.

Basic Information

Product Name	trans-3-Hydroxy-3-Methylcyclobutane-1-Methamine Hydrochloride
CAS No.	2231664-53-0
Molecular Formula	C7H15NO2•HCl
Molecular Weight	181.66 g/mol (Free base: 145.20 g/mol)
Synonyms	(1r,3r)-3-Aminomethyl-3-methylcyclobutanol hydrochloride; trans-3-(Aminomethyl)-3-methylcyclobutanol hydrochloride; (1R,3R)-3-(Aminomethyl)-3-methylcyclobutanol hydrochloride; 3-Hydroxy-3-methylcyclobutane-1-methanamine hydrochloride (trans-); trans-3-Methyl-3-aminomethylcyclobutanol hydrochloride; (1R,3R)-3-Hydroxy-3-methylcyclobutanemethanamine hydrochloride; Cyclobutanol, 3-(aminomethyl)-3-methyl-, hydrochloride, (1R,3R)-
EINECS	Contact for details

Quality Control

Our trans-3-Hydroxy-3-Methylcyclobutane-1-Methamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. A detailed Certificate of Analysis (COA) providing HPLC/GC purity, chiral HPLC data, water content (KF), residue on ignition, and identification (IR/NMR) is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.