Description

Benzoic Acid, 3-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical Suzuki-Miyaura cross-coupling reagent, enabling the efficient construction of complex fluorinated aromatic scaffolds. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require precise, reliable building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate fluorinated aromatic motifs for enhanced efficacy and stability.
• Material Science Research: Employed in the creation of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where fluorinated units improve charge transport and device performance.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel bidentate ligands and organoboron catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	Benzoic Acid, 3-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester
CAS No.	2231129-85-2
Molecular Formula	C14H18BFO4
Molecular Weight	280.10 g/mol
Synonyms	2-Fluoro-6-(methoxycarbonyl)phenylboronic acid pinacol ester; Methyl 3-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; (3-Fluoro-2-methoxycarbonylphenyl)boronic acid pinacol ester; Methyl 2-(pinacolatoboryl)-3-fluorobenzoate; 2-(Pinacolatoboryl)-3-fluorobenzoic acid methyl ester; Boronic ester of methyl 3-fluoro-2-boronobenzoate
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 3-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 19F, 11B), and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical specifications. Our quality commitment supports compliance with ISO, GMP, and relevant regulatory frameworks for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.