Description

(3H-Diazirine-3,3-Diyl)Dimethanol CAS NO 2231099-59-3 is a specialized diazirine-based bifunctional crosslinking reagent, a key building block in advanced photochemistry and bioconjugation. Its core value lies in its ability to form highly reactive carbene intermediates upon photoactivation, enabling the formation of covalent bonds with a wide range of biological and synthetic targets under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require precise and efficient crosslinking strategies.

Application

• Photoaffinity Labeling (PAL): A critical reagent for mapping protein-ligand interactions and identifying binding sites in drug discovery.
• Bioconjugation & Probe Synthesis: Used to create photoactivatable crosslinkers for attaching fluorophores, biotin, or other tags to biomolecules like proteins and nucleic acids.
• Polymer & Surface Modification: Enables the photochemical grafting of functional groups onto polymer backbones or material surfaces for creating smart materials.
• Chemical Biology Tool Development: Serves as a precursor for synthesizing novel diazirine-containing probes for live-cell imaging and interactome studies.
• Proteomics Research: Facilitates crosslinking mass spectrometry (XL-MS) workflows to study protein structures and complex protein-protein interactions.
• Antibody-Drug Conjugate (ADC) Research: Investigated for developing novel, light-triggered linker technologies in targeted therapeutics.

Basic Information

Product Name	(3H-Diazirine-3,3-Diyl)Dimethanol
CAS No.	2231099-59-3
Molecular Formula	C4H8N2O2
Molecular Weight	116.12 g/mol
Synonyms	3,3-Bis(hydroxymethyl)diaziridine; Diaziridine-3,3-dimethanol; 3,3-Di(hydroxymethyl)diaziridine; 3,3-Bis(methanol)diaziridine; Diaziridine-3,3-diylbis(methanol); (Diaziridine-3,3-diyl)dimethanol; 3,3-Dihydroxymethyldiaziridine; Bifunctional Diazirine Crosslinker
EINECS	Contact for details

Quality Control

Our (3H-Diazirine-3,3-Diyl)Dimethanol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and FT-IR for identification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C (refrigerated) under an inert atmosphere such as argon or nitrogen. The compound is light-sensitive and should be handled under subdued lighting conditions. Allow the container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.