Description

Cho-Ch2-Peg2-Ch2Tbu-Ester CAS NO 2230956-95-1 is a specialized bifunctional PEG derivative designed for advanced bioconjugation and linker chemistry. This compound is engineered to provide a stable, hydrophilic spacer arm, facilitating the attachment of active molecules in pharmaceutical and diagnostic applications. It is an essential intermediate for researchers and manufacturers in the fields of ADC (Antibody-Drug Conjugate) development, prodrug synthesis, and polymer-based drug delivery systems.

Application

• ADC (Antibody-Drug Conjugate) Linker: Serves as a key component in constructing cleavable or non-cleavable linkers for targeted cancer therapies.
• Prodrug Synthesis: Used to create water-soluble prodrugs by conjugating hydrophobic active pharmaceutical ingredients (APIs) via its ester functionality.
• Polymer Therapeutics: Acts as a functional monomer or cross-linker in the synthesis of biodegradable and biocompatible polymeric carriers for controlled drug release.
• Diagnostic Reagent Conjugation: Facilitates the labeling of antibodies, proteins, or peptides with dyes, radionuclides, or contrast agents for imaging and assays.
• Surface Modification: Employed to PEGylate nanoparticles, liposomes, or solid surfaces to enhance biocompatibility and circulation time.
• Biomaterial Functionalization: Used to introduce reactive ester groups onto hydrogels or scaffolds for subsequent coupling with biomolecules.

Basic Information

Item	Detail
Product Name	Cho-Ch2-Peg2-Ch2Tbu-Ester
CAS No.	2230956-95-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cholesterol-PEG2-t-butyl ester; (3β)-Cholest-5-en-3-yl 3,6,9,12,15-pentaoxaoctadecan-18-oate; Cholesterol-(ethylene glycol)2-t-butyl ester; t-Butyl-PEG2-Cholesterol ester; Hydrophobic PEG linker; Bifunctional PEG cholesterol derivative; ADC linker intermediate; Prodrug linker
EINECS	Contact for details

Quality Control

Every batch of Cho-Ch2-Peg2-Ch2Tbu-Ester is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical parameters are provided with each shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.