Description

5H-Pyrrolo[2,3-B]Pyrazine, 2-Fluoro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Triphenylmethyl)- is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound is a critical pharmaceutical intermediate, specifically engineered for use in Suzuki-Miyaura cross-coupling reactions to construct complex heterocyclic scaffolds. It is essential for researchers and manufacturers in drug discovery and development, particularly for creating novel active pharmaceutical ingredients (APIs) in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: The boronic ester pinacol group enables efficient, palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a high-purity starting material for scaling up API synthesis under cGMP conditions.
• Chemical Biology Probes: Facilitates the creation of labeled compounds for target identification and validation studies.
• Agrochemical Research: Potential intermediate in the development of new herbicides and fungicides with complex heterocyclic structures.
• Material Science: Exploration of organic electronic materials and ligands for catalytic systems.

Basic Information

Product Name	5H-Pyrrolo[2,3-B]Pyrazine, 2-Fluoro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Triphenylmethyl)-
CAS No.	2230713-66-1
Molecular Formula	C33H33BFN3O2
Molecular Weight	533.45 g/mol
Synonyms	2-Fluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(triphenylmethyl)-5H-pyrrolo[2,3-b]pyrazine; 2-Fluoro-5-trityl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7H-pyrrolo[2,3-b]pyrazine; 5-Trityl-2-fluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5H-pyrrolo[2,3-b]pyrazine; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-5-(triphenylmethyl)-5H-pyrrolo[2,3-b]pyrazine; CAS 2230713-66-1
EINECS	Contact for details

Quality Control

Our 5H-Pyrrolo[2,3-B]Pyrazine derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to standards suitable for research and cGMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.